Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Paulovich Lab at Fred Hutch (https://research.fredhutch.org/paulovich/en.html) is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine via patient selection and characterization of novel therapeutic targets. The lab has a major focus on mass spectrometry (MS)-based proteomics (both untargeted and targeted), as well as integrating proteomic data with genomic data. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity within the Paulovich lab for a highly motivated and experienced full-time Staff Scientist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing bench-level experiments in support of proteomic, genomic, and transcriptomic analyses of clinical and preclinical biospecimens. The ideal candidate will be able to work as part of a team as well as independently to follow established standard operating protocols (SOP) in a CLIA/CAP laboratory environment.

Responsibilities

• Work with antibodies (immunoaffinity purification, immobilization on solid supports, ELISAs)
• Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
• Assist in generation and analysis of mass spectrometry (MS)-based proteomic data
• Follow standard operating protocols (SOP) in a CLIA/CAP laboratory environment including participating in annual competency and proficiency testing
• Collaborate effectively with an interdisciplinary team spanning expertise in medicine, biology, analytical chemistry, and statistics
• Maintain laboratory equipment, records, research results files, and databases
• Write progress reports and develop standard operating protocols (SOPs)
• Write and co-author scientific manuscripts (in peer-reviewed journals)
• Design and present Powerpoint presentations from results to colleagues and collaborators
• Work comfortably in a milestone-driven environment, with quarterly objectives
• Perform other duties as required

Qualifications

MINIMUM QUALIFICATIONS:

• Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline
• Previous work maintaining mass spectrometry and HPLC instruments
• Staff Scientist position requires approval from the division Appointments and Promotions Committee depending on experience of the applicant

PREFERRED QUALIFICATIONS:

• Exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintain records
• Excellent English writing and oral communication skills
• Proficiency with MS Office programs (Word, Powerpoint, Excel, and Access)
• Ability to multi-task efficiently in a highly interactive, interdisciplinary team environment
• Comfort in a milestone-driven environment, with quarterly objectives
• Willingness to learn new techniques
• Strong work ethic
• Previous experience in a CLIA/CAP or similar clinical lab environment
• Experience with LIMS, database software and proteomics tools
• Previous work with antibodies and peptide standards (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
• Previous work in proteomics, genomics, and functional biology
• Previous experience with liquid handling robot usage and programming
• Ability to perform molecular biology and biochemistry experiments on human and animal biospecimens and cell lines

The annual base salary range for this position is from $82,118 to $185,016 and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance.

This position may be eligible for sign on bonus. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).

Additional Information